Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Scap is a polytopic membrane protein that functions as a molecular machine to control the
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …

Cholesterol is an essential lipid and its synthesis is nutritionally and energetically costly,. In
mammals, cholesterol biosynthesis increases after feeding and is inhibited under fasting …

The endoplasmic reticulum (ER) is a large, dynamic, and multifunctional organelle. ER
protein homeostasis is essential for the coordination of its diverse functions and depends on …

Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the
deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the …

Protein homeostasis mechanisms are fundamentally important to match cellular needs and
to counteract stress conditions. A fundamental challenge is to understand how defective …

Cholesterol is an essential component of animal cell membranes, and its concentration is
tightly controlled by a feedback system that operates at transcriptional and …

Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of
cells and organisms. Cells rely on a sophisticated but poorly understood network of …

Statins are inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol
biosynthesis, and have been clinically used to treat cardiovascular disease. However, a …

Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested
in the diet. By modulating the activity of many proteins [eg, liver X receptors (LXRs), oxysterol …