ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …

Abstract Poly (ADP‐ribose) polymerase (PARP) enzymes, especially PARP1, play important
roles in the DNA damage response and in the maintenance of genome stability, which …

PARP1, an established anti-cancer target that regulates many cellular pathways, including
DNA repair signaling, has been intensely studied for decades as a poly (ADP-ribosyl) …

We report here chemoenzymatic and fully synthetic methodologies to modify aspartate and
glutamate side chains with ADP-ribose at specific sites on peptides. Structural analysis of …

We describe the development and optimization of a methodology to prepare peptides and
proteins modified on the arginine residue with an adenosine-di-phosphate-ribosyl (ADPr) …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) activity is regulated by its co-factor
histone poly (ADP-ribosylation) factor 1 (HPF1). The complex formed by HPF1 and PARP1 …

Adenosine diphosphate ribosylation (ADP-ribosylation) is a crucial post-translational
modification involved in important regulatory mechanisms of numerous cellular pathways …

Glycoproteins play crucial roles in various biological processes. To investigate the
relationship between glycan structure and function, researchers have employed various …

Serine ADP-ribosylation (ADPr) is a DNA damage-induced post-translational modification
catalyzed by the PARP1/2: HPF1 complex. As the list of PARP1/2: HPF1 substrates …

The transfer of an adenosine diphosphate (ADP) ribose moiety to a nucleophilic side chain
by consumption of nicotinamide adenine dinucleotide is referred to as ADP‐ribosylation …