As one of the most representative hypoxic enzymes, nitroreductases (NTRs) play
momentous roles in malignant tumor progression, metastasis, invasion and angiogenesis …

Hypoxia, a common feature of most solid tumors, plays an important role in tumor
proliferation, metastasis, and invasion, leading to drug, radiation, and photodynamic therapy …

Nitroreductase (NTR), a common enzymatic biomarker of hypoxia, is widely used to evaluate
tumor microenvironments. To date, numerous optical probes have been reported for NTRs …

Targeting small-molecule fluorescent indicators using genetically encoded protein tags
yields new hybrid sensors for biological imaging. Optimization of such systems requires …

Many biomacromolecules are known to cluster in microdomains with specific subcellular
localization. In the case of enzymes, this clustering greatly defines their biological functions …

Selectively labeling cells with damaged membranes is needed not only for identifying dead
cells in culture, but also for imaging membrane barrier dysfunction in pathologies in vivo …

Synthetic CRISPR-based gene-drive systems have tremendous potential in public health
and agriculture, such as for fighting vector-borne diseases or suppressing crop pest …

Nitroreductases, enzymes found mostly in bacteria and also in few eukaryotes, use
nicotinamide adenine dinucleotide (NADH) or nicotinamide adenine dinucleotide phosphate …

Nitroaromatic compounds (ArNO2) maintain their importance in relation to industrial
processes, environmental pollution, and pharmaceutical application. The manifestation of …

Cell surface receptors transmit extracellular information into cells. Spatiotemporal regulation
of receptor signaling is crucial for cellular functions, and dysregulation of signaling causes …