Alzheimer's disease (AD) is a chronic disabling disease that affects the central nervous
system. The main consequences of AD include the decline of cognitive functions and …

Background. Cholinesterases are a group of serine hydrolases that split the neurotransmitter
acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and …

Chemical warfare agents constitute one of the greatest threats in the modern world. Among
them, the neurotoxic agents are of special interest due to their high lethality and danger …

Huperzine A (HupA) is found in an extract from a club moss that has been used for centuries
in Chinese folk medicine. Its action has been attributed to its ability to strongly inhibit …

In accordance with its biological role, termination of neurotransmission at cholinergic
synapses by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase is …

(-)-Galantamine (1){(4aS, 6R, 8aS)-4a, 5, 9, 10, 11, 12-hexahydro-3-methoxy-11-methyl-6H-
benzofuro [3a, 3, 2-ef][2]-benzazepin-6-ol}(Chart 1), an alkaloid isolated from the Caucasian …

The crystal structure of the snake toxin fasciculin, bound to mouse acetylcholinesterase
(mAChE), at 3.2 Å resolution reveal sa synergistic three-point anchorage consistent with the …

The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …

The enzyme acetylcholinesterase generates a strong electrostatic field that can attract the
cationic substrate acetylcholine to the active site. However, the long and narrow active site …

Abstract Background: Fasciculin (FAS), a 61-residue polypeptide purified from mamba
venom, is a three-fingered toxin which is a powerful reversible inhibitor of …