Genetic studies in animals and humans indicate that gene mutations that functionally perturb
transforming growth factor β (TGF-β) signaling are linked to specific hereditary vascular …

The transforming growth factor β (TGF-β) family of growth factors control the development
and homeostasis of most tissues in metazoan organisms. Work over the past few years has …

Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder
characterized by multisystemic vascular dysplasia and recurrent haemorrhage. Linkage for …

Transforming growth factor-β (TGF-β) family members, which include TGF-βs, activins and
bone morphogenetic proteins, are pleiotropic cytokines that elicit cell type-specific effects in …

Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and
its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been …

Angiogenesis is the propelling force for tumor growth and metastasis, and antiangiogenic
therapy represents one of the most promising modalities for cancer treatment. CD105 …

Endothelial dysfunction is one of the earliest indicators of cardiovascular (CV) dysfunction,
and its evaluation would be of considerable importance to stratify CV risk of many diseases …

Deregulation of precursor mRNA splicing is associated with many illnesses and has been
linked to age‐related chronic diseases. Here we review recent progress documenting how …

Endoglin (CD105) is a transmembrane glycoprotein that binds transforming growth factor
(TGF)-β1 and-β3, and coprecipitates with the Ser/Thr kinase signaling receptor complex by …

The last fifteen years have seen an explosive progress in our knowledge of how cell
proliferation and differentiation are regulated by extracellular factors. A few growth factors …