Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …

Evolving understanding of structural and biological complexity of tumors has stimulated
development of physiologically relevant tumor models for cancer research and drug …

The incidence and mortality rates of prostate cancer are significantly higher in African-
American men when compared with European-American men. We tested the hypothesis that …

Notch signaling plays a critical role in the pathogenesis and progression of human
malignancies but the precise role and mechanism of Notch-1 for tumor invasion remains …

Abstract The Forkhead Box M1 (FoxM1) transcription factor has been shown to play
important roles in regulating the expression of genes involved in cell proliferation …

BACKGROUND Hematopoietic cells home to bone by means of chemo‐attraction to marrow
chemokines, and interaction of chemokines with their receptors leads to the …

Increased osteoclastogenesis and angiogenesis occur in physiologic and pathologic
conditions. However, it is unclear if or how these processes are linked. To test the …

Matrix metalloproteinases (MMPs) play an important role in degeneration of the matrix
associated with bone and cartilage. Regulation of osteoclast activity is essential in the …

The field of cell therapy and regenerative medicine can hold the promise of restoring normal
tissues structure and function. Additionally, the main targets of stem cell-based therapies are …

Cancer cells proliferate, differentiate and migrate by repurposing physiological signalling
mechanisms. In particular, altered calcium signalling is emerging as one of the most …