Cotranslational mechanisms of protein biogenesis and complex assembly in eukaryotes
F Morales-Polanco, JH Lee… - Annual review of …, 2022 - annualreviews.org
The formation of protein complexes is crucial to most biological functions. The cellular
mechanisms governing protein complex biogenesis are not yet well understood, but some …
mechanisms governing protein complex biogenesis are not yet well understood, but some …
[HTML][HTML] Regulation of gene expression via translational buffering
Translation of an mRNA represents a critical step during the expression of protein-coding
genes. As mechanisms governing post-transcriptional regulation of gene expression are …
genes. As mechanisms governing post-transcriptional regulation of gene expression are …
Cohesin prevents cross-domain gene coactivation
The contrast between the disruption of genome topology after cohesin loss and the lack of
downstream gene expression changes instigates intense debates regarding the structure …
downstream gene expression changes instigates intense debates regarding the structure …
Single-cell new RNA sequencing reveals principles of transcription at the resolution of individual bursts
D Ramsköld, GJ Hendriks, AJM Larsson, JV Mayr… - Nature Cell …, 2024 - nature.com
Analyses of transcriptional bursting from single-cell RNA-sequencing data have revealed
patterns of variation and regulation in the kinetic parameters that could be inferred. Here we …
patterns of variation and regulation in the kinetic parameters that could be inferred. Here we …
3D chromatin architecture, BRD4, and Mediator have distinct roles in regulating genome-wide transcriptional bursting and gene network
Discontinuous transcription is evolutionarily conserved and a fundamental feature of gene
regulation; yet, the exact mechanisms underlying transcriptional bursting are unresolved …
regulation; yet, the exact mechanisms underlying transcriptional bursting are unresolved …
Synthetic analysis of chromatin tracing and live-cell imaging indicates pervasive spatial coupling between genes
The role of the spatial organization of chromosomes in directing transcription remains an
outstanding question in gene regulation. Here, we analyze two recent single-cell imaging …
outstanding question in gene regulation. Here, we analyze two recent single-cell imaging …
Diffusion-enhanced characterization of 3D chromatin structure reveals its linkage to gene regulatory networks and the interactome
Y He, Y Xue, J Wang, Y Huang, L Liu, Y Huang… - Genome …, 2023 - genome.cshlp.org
The interactome networks at the DNA, RNA, and protein levels are crucial for cellular
functions, and the diverse variations of these networks are heavily involved in the …
functions, and the diverse variations of these networks are heavily involved in the …
Regulatory mechanisms ensuring coordinated expression of functionally related genes
Coordinated spatiotemporal expression of large sets of genes is required for the
development and homeostasis of organisms. To achieve this goal, organisms use myriad …
development and homeostasis of organisms. To achieve this goal, organisms use myriad …
Shared regulation and functional relevance of local gene co-expression revealed by single cell analysis
D M. Ribeiro, C Ziyani, O Delaneau - Communications biology, 2022 - nature.com
Most human genes are co-expressed with a nearby gene. Previous studies have revealed
this local gene co-expression to be widespread across chromosomes and across dozens of …
this local gene co-expression to be widespread across chromosomes and across dozens of …
Genes enriched in A/T-ending codons are co-regulated and conserved across mammals
Codon usage influences gene expression distinctly depending on the cell context. Yet, the
importance of codon bias in the simultaneous turnover of specific groups of protein-coding …
importance of codon bias in the simultaneous turnover of specific groups of protein-coding …