Most eukaryotic mRNAs are translated in a cap-dependent fashion; however, under stress
conditions, the cap-independent translation driven by internal ribosomal entry sites (IRESs) …

The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

Carcinogenesis is a mechanistically complex and variable process with a plethora of
underlying genetic causes. Cancer development comprises a multitude of steps that occur …

Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …

The cellular stress response corresponds to the molecular changes that a cell undergoes in
response to various environmental stimuli. It induces drastic changes in the regulation of …

Cells respond to stress stimuli through coordinated changes in gene expression. The
regulation of translation is often used under these circumstances because it allows …

Gene expression is finely regulated at the post-transcriptional level. Features of the
untranslated regions of mRNAs that control their translation, degradation and localization …

Initiation of translation of most eukaryotic mRNAs commences with 5 end–dependent
recruitment of 40S ribosomal subunits to the mRNA. The 40S subunit carrying the initiator …

Brain ischemia and reperfusion engage multiple independently-fatal terminal pathways
involving loss of membrane integrity in partitioning ions, progressive proteolysis, and …

Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …