Bacterial sphingomyelinases and phospholipases are a heterogeneous group of esterases
which are usually surface associated or secreted by a wide variety of Gram-positive and …

Rab molecular switches are key players in defining membrane identity and regulating
intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity …

L egionella species are ubiquitous, waterborne bacteria that thrive in numerous ecological
niches. Yet, in contrast to many other environmental bacteria, L egionella spp. are also able …

Intravacuolar pathogens need to gradually expand their surrounding vacuole to
accommodate the growing number of bacterial offspring during intracellular replication. Here …

To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …

Legionella pneumophila, a Gram-negative intracellular bacterium, is one of the major
causes of Legionnaires' disease, a specific type of atypical pneumonia. Despite intensive …

Intracellular bacteria have developed numerous strategies to hijack host vesicular trafficking
pathways to form their unique replicative niches. To promote intracellular replication, the …

To replicate within host cells, bacterial pathogens must acquire host-derived nutrients while
avoiding degradative antimicrobial pathways. Fundamental insights into bacterial …

The facultative intracellular pathogen Legionella pneumophila, the causative agent of
Legionnaires disease, infects and replicates within human alveolar macrophages. L …

Legionella pneumophila is the causative agent of a severe pneumonia called Legionnaires'
disease. The environmental bacterium replicates in free-living amoebae as well as in lung …