Bioactivity, health benefits, and related molecular mechanisms of curcumin: Current progress, challenges, and perspectives

XY Xu, X Meng, S Li, RY Gan, Y Li, HB Li - Nutrients, 2018 - mdpi.com
Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used
as a spice in cooking and a yellow pigment in the food processing industry. Recent studies …

SERCA control of cell death and survival

ER Chemaly, L Troncone, D Lebeche - Cell calcium, 2018 - Elsevier
Abstract Intracellular calcium (Ca 2+) is a critical coordinator of various aspects of cellular
physiology. It is increasingly apparent that changes in cellular Ca 2+ dynamics contribute to …

Mitochondrial fission causes cisplatin resistance under hypoxic conditions via ROS in ovarian cancer cells

Y Han, B Kim, U Cho, IS Park, SI Kim… - Oncogene, 2019 - nature.com
Mitochondria undergo fission and fusion continually for survival through the course of
cellular adaption processes in response to changes in the surrounding environment …

Curcumin exerts a protective effect against premature ovarian failure in mice

Z Yan, Y Dai, H Fu, Y Zheng, D Bao… - Journal of …, 2018 - jme.bioscientifica.com
This study was designed to investigate the protective effect of curcumin against d-galactose
(d-gal)-induced premature ovarian failure (POF) in mice. A mouse POF model was induced …

A review of biologically active flavonoids as inducers of autophagy and apoptosis in neoplastic cells and as cytoprotective agents in non‐neoplastic cells

MS D'Arcy - Cell biology international, 2022 - Wiley Online Library
Phytochemicals are a diverse group of compounds found in various fruits, vegetables, nuts,
and legumes. Many phytochemicals have been observed to possess health benefits. Some …

[HTML][HTML] Cell death as a result of calcium signaling modulation: A cancer-centric prospective

A Danese, S Leo, A Rimessi, MR Wieckowski… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract Calcium ions (Ca 2+) and the complex regulatory system governed by Ca 2+
signaling have been described to be of crucial importance in numerous aspects related to …

In vitro assays and techniques utilized in anticancer drug discovery

MK Ediriweera, KH Tennekoon… - Journal of Applied …, 2019 - Wiley Online Library
Abstract Development of a cancer is a multistep process and six major hallmarks of cancer
that are known to control malignant transformation have been described. Anticancer drug …

[HTML][HTML] STAT3 signaling in ovarian cancer: a potential therapeutic target

R Liang, X Chen, L Chen, F Wan, K Chen, Y Sun… - Journal of …, 2020 - ncbi.nlm.nih.gov
Accumulating evidence has shown that Signal Transducer and Activator of Transcription 3
(STAT3) is thought to be a promising target for cancer therapy as STAT3 is frequently …

The Interplay between Ca2+ Signaling Pathways and Neurodegeneration

RP Ureshino, AG Erustes, TB Bassani… - International journal of …, 2019 - mdpi.com
Calcium (Ca2+) homeostasis is essential for cell maintenance since this ion participates in
many physiological processes. For example, the spatial and temporal organization of Ca2+ …

Curcumin induces autophagy, apoptosis, and cell cycle arrest in human pancreatic cancer cells

Y Zhu, S Bu - Evidence‐Based Complementary and Alternative …, 2017 - Wiley Online Library
Objective. Curcumin is an active extract from turmeric. The aim of this study was to identify
the underlying mechanism of curcumin on PCa cells and the role of autophagy in this …