Microbial infections are recognized by the innate immune system both to elicit immediate
defense and to generate long-lasting adaptive immunity. To detect and respond to vastly …

Simple Summary Anti-PD-1/PD-L1 and anti-CTLA-4-based immune checkpoint blockade
(ICB) immunotherapy have recently emerged as a breakthrough in human cancer treatment …

Osteopontin (OPN) is a multifunctional phosphorylated protein. It is widely involved in solid
tumor progression, such as intensification of macrophage recruitment, inhibition of T-cell …

Dietary fiber, with intake of soluble fibers in particular, has been reported to lower the risk for
developing inflammatory bowel diseases (IBD). This is at least partly attributable to the …

Aryl hydrocarbon receptor (AHR) agonists are promising immunomodulators that potentially
maintain immune tolerance. In this study, we examined the ability of indole-3-pyruvic acid …

Osteopontin (OPN) is a multifunctional protein, initially identified in osteosarcoma cells with
its role of mediating osteoblast adhesion. Later studies revealed that OPN is associated with …

Since its initial identification as one of the genes most highly upregulated upon T-cell
activation, osteopontin (or Eta-1, as it was designated then) has been demonstrated to have …

Expression of Itgax (encoding the CD11c surface protein) and Spp1 (encoding osteopontin;
OPN) has been associated with activated microglia that can develop in healthy brains and …

Osteopontin (OPN) is a multifunctional cytokine and adhesion molecule, as well as an
unusual regulator for both innate and adaptive immune responses. Several immune cells …

Background Both inflammatory bowel disease (IBD) and hepato‐pancreato‐biliary cancers
(HPBC) have been established to cause a huge socioeconomic burden. Epidemiological …