Skin whitening agents: Medicinal chemistry perspective of tyrosinase inhibitors

T Pillaiyar, M Manickam… - Journal of enzyme …, 2017 - Taylor & Francis
Melanogenesis is a process to synthesize melanin, which is a primary responsible for the
pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and …

Recognition moieties of small molecular fluorescent probes for bioimaging of enzymes

X Wu, W Shi, X Li, H Ma - Accounts of chemical research, 2019 - ACS Publications
Conspectus Enzymes are a class of important substances for life, and their abnormal levels
are associated with many diseases. Thus, great progress has been made in the past decade …

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis

I Carballo-Carbajal, A Laguna… - Nature …, 2019 - nature.com
In Parkinson's disease (PD) there is a selective degeneration of neuromelanin-containing
neurons, especially substantia nigra dopaminergic neurons. In humans, neuromelanin …

Inhibitors of melanogenesis: an updated review

T Pillaiyar, V Namasivayam, M Manickam… - Journal of medicinal …, 2018 - ACS Publications
Melanins are pigment molecules that determine the skin, eye, and hair color of the human
subject to its amount, quality, and distribution. Melanocytes synthesize melanin and provide …

Neuromelanin in Parkinson's disease: tyrosine hydroxylase and tyrosinase

T Nagatsu, A Nakashima, H Watanabe, S Ito… - International journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is an aging-related disease and the second most common
neurodegenerative disease after Alzheimer's disease. The main symptoms of PD are …

Recent development of signaling pathways inhibitors of melanogenesis

T Pillaiyar, M Manickam, SH Jung - Cellular signalling, 2017 - Elsevier
Human skin, eye and hair color rely on the production of melanin, depending on its quantity,
quality, and distribution, Melanin plays a monumental role in protecting the skin against the …

Recent progress in fluorescent molecular systems for the detection of disease-related biomarkers in biofluids

RR Nair, JM An, J Kim, D Kim - Coordination Chemistry Reviews, 2023 - Elsevier
The use of biofluids as a diagnostic tool for chronic health conditions has been gaining
traction in recent years. These fluids, which can be obtained non-invasively (such as urine …

Fluorescent probes for visualizing ROS-associated proteins in disease

H Wang, X Wang, P Li, M Dong, SQ Yao, B Tang - Chemical Science, 2021 - pubs.rsc.org
Abnormal expression of proteins, including catalytic and expression dysfunction, is directly
related to the development of various diseases in living organisms. Reactive oxygen species …

Near‐infrared fluorescent probe with new recognition moiety for specific detection of tyrosinase activity: design, synthesis, and application in living cells and zebrafish

X Wu, L Li, W Shi, Q Gong, H Ma - … Chemie International Edition, 2016 - Wiley Online Library
Fluorescence imaging of tyrosinase (a cancer biomarker) in living organisms is of great
importance for biological studies. However, selective detection of tyrosinase remains a great …

A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery

T Pillaiyar, S Meenakshisundaram, M Manickam… - European journal of …, 2020 - Elsevier
Drug repurposing is a strategy consisting of finding new indications for already known
marketed drugs used in various clinical settings or highly characterized compounds despite …