Covering: up to 2012 With the recent structural characterization of each of the component
enzymes of type I polyketide synthases, scientists are coming tantalizingly close to …

Chemotherapy is one of the main treatments used to combat cancer. A great number of
antitumor compounds are natural products or their derivatives, mainly produced by …

FA (fatty acid) synthesis represents a central, conserved process by which acyl chains are
produced for utilization in a number of end-products such as biological membranes. Central …

Mycobacterium abscessus, a relative of Koch's bacillus (the bacterium that causes
tuberculosis), has recently emerged as the cause of an increasing number of both …

Biological treatment of saline wastewater is considered unfavorable due to salinity inhibition
on microbial activity. In this study, intertidal wetland sediment (IWS) collected from a high …

Polyketide synthases (PKSs) catalyze biosynthesis of a diverse family of pharmaceutically
important secondary metabolites. Bioinformatics analysis of sequence and structural …

All organisms that produce fatty acids do so via a repeated cycle of reactions. In mammals
and other animals, these reactions are catalyzed by a type I fatty acid synthase (FAS), a …

Covering: 2002 to September 2009 In recent years, a number of gene clusters involved in
the biosynthesis of polyketide compounds have been characterized and the genes have …

Covering: up to October 2008Antitumor compounds produced by actinomycetes and novel
derivatives generated by combinatorial biosynthesis are reviewed (with 318 references …

The recent discovery of fatty acyl-AMP ligases (FAALs) in Mycobacterium tuberculosis (Mtb)
provided a new perspective of fatty acid activation. These proteins convert fatty acids to the …