Immune responses to human fungal pathogens and therapeutic prospects

MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

[HTML][HTML] The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly

F Zhang, D Aschenbrenner, JY Yoo, T Zuo - The Lancet Microbe, 2022 - thelancet.com
The gut mycobiome (fungi) is a small but crucial component of the gut microbiome in
humans. Intestinal fungi regulate host homoeostasis, pathophysiological and physiological …

A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors

AB Dohlman, J Klug, M Mesko, IH Gao, SM Lipkin… - Cell, 2022 - cell.com
Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the
human microbiome, yet little is known about their role in human cancers. Pan-cancer …

The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells

NN Liu, CX Yi, LQ Wei, JA Zhou, T Jiang, CC Hu… - Cancer Cell, 2023 - cell.com
Although polymorphic microbiomes have emerged as hallmarks of cancer, far less is known
about the role of the intratumor mycobiome as living microorganisms in cancer progression …

Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19

T Kusakabe, WY Lin, JG Cheong, G Singh… - Nature …, 2023 - nature.com
Gastrointestinal fungal dysbiosis is a hallmark of several diseases marked by systemic
immune activation. Whether persistent pathobiont colonization during immune alterations …

[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system

TCA Hitch, LJ Hall, SK Walsh, GE Leventhal, E Slack… - Mucosal …, 2022 - Elsevier
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …

Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn's disease

GR Martini, E Tikhonova, E Rosati, MB DeCelie… - Nature medicine, 2023 - nature.com
Aberrant CD4+ T cell reactivity against intestinal microorganisms is considered to drive
mucosal inflammation in inflammatory bowel diseases. The disease-relevant microbial …

Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts

L Ning, YL Zhou, H Sun, Y Zhang, C Shen… - Nature …, 2023 - nature.com
The perturbations of the gut microbiota and metabolites are closely associated with the
progression of inflammatory bowel disease (IBD). However, inconsistent findings across …

Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease

S Zeng, E Rosati, C Saggau, B Messner, H Chu… - Cell host & …, 2023 - cell.com
Alcohol-associated liver disease is accompanied by intestinal mycobiome dysbiosis, yet the
impacts on liver disease are unclear. We demonstrate that Candida albicans-specific T …

Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization

YH Chen, F Yeung, KA Lacey, K Zaldana, JD Lin… - Science …, 2023 - science.org
The paucity of blood granulocyte populations such as neutrophils in laboratory mice is a
notable difference between this model organism and humans, but the cause of this species …