Immune responses to human fungal pathogens and therapeutic prospects
MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …
[HTML][HTML] The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly
The gut mycobiome (fungi) is a small but crucial component of the gut microbiome in
humans. Intestinal fungi regulate host homoeostasis, pathophysiological and physiological …
humans. Intestinal fungi regulate host homoeostasis, pathophysiological and physiological …
A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors
AB Dohlman, J Klug, M Mesko, IH Gao, SM Lipkin… - Cell, 2022 - cell.com
Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the
human microbiome, yet little is known about their role in human cancers. Pan-cancer …
human microbiome, yet little is known about their role in human cancers. Pan-cancer …
The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells
NN Liu, CX Yi, LQ Wei, JA Zhou, T Jiang, CC Hu… - Cancer Cell, 2023 - cell.com
Although polymorphic microbiomes have emerged as hallmarks of cancer, far less is known
about the role of the intratumor mycobiome as living microorganisms in cancer progression …
about the role of the intratumor mycobiome as living microorganisms in cancer progression …
Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19
Gastrointestinal fungal dysbiosis is a hallmark of several diseases marked by systemic
immune activation. Whether persistent pathobiont colonization during immune alterations …
immune activation. Whether persistent pathobiont colonization during immune alterations …
[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …
Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn's disease
GR Martini, E Tikhonova, E Rosati, MB DeCelie… - Nature medicine, 2023 - nature.com
Aberrant CD4+ T cell reactivity against intestinal microorganisms is considered to drive
mucosal inflammation in inflammatory bowel diseases. The disease-relevant microbial …
mucosal inflammation in inflammatory bowel diseases. The disease-relevant microbial …
Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts
L Ning, YL Zhou, H Sun, Y Zhang, C Shen… - Nature …, 2023 - nature.com
The perturbations of the gut microbiota and metabolites are closely associated with the
progression of inflammatory bowel disease (IBD). However, inconsistent findings across …
progression of inflammatory bowel disease (IBD). However, inconsistent findings across …
Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease
S Zeng, E Rosati, C Saggau, B Messner, H Chu… - Cell host & …, 2023 - cell.com
Alcohol-associated liver disease is accompanied by intestinal mycobiome dysbiosis, yet the
impacts on liver disease are unclear. We demonstrate that Candida albicans-specific T …
impacts on liver disease are unclear. We demonstrate that Candida albicans-specific T …
Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization
The paucity of blood granulocyte populations such as neutrophils in laboratory mice is a
notable difference between this model organism and humans, but the cause of this species …
notable difference between this model organism and humans, but the cause of this species …