Human adenoviruses (HAdV) are one of the most important pathogens detected in acute
respiratory diseases in pediatrics and immunocompromised patients. In 1953, Wallace …

An adenoviral (AdV)-based vector system is a promising platform for vaccine development
and gene therapy applications. Administration of an AdV vector elicits robust innate …

The liver is a vital organ that functions to detoxify the body. Liver cancer and infectious
diseases such as influenza and malaria can fatally compromise liver function. mRNA …

The COVID-19 pandemic has motivated the rapid development of numerous vaccines that
have proven effective against SARS-CoV-2. Several of these successful vaccines are based …

Both human and non-human simian adenoviruses (HAdVs and SAdVs, respectively) have
been used as gene therapy and vaccine vectors. The high prevalence of HAdVs and the …

Short chain fatty acids (SCFAs) are major gut metabolites that are involved in the regulation
of dysfunction in immune responses, such as autoimmunity and cytokine storm. Numerous …

Introduction Nonhuman adenoviral (AdV) gene delivery platforms have significant value due
to their ability to elude preexisting AdV vector immunity in most individuals. Previously, we …

The nucleoprotein (NP) is a vital target for the heterosubtypic immunity of CD8+ cytotoxic T
lymphocytes (CTLs) due to its conservation among influenza virus subtypes. To further …

Cancer is one of the foremost causes of mortality. The human genome remains stable over
time. However, human activities and environmental factors have the power to influence the …

It is necessary to develop universal vaccines that act broadly and continuously to combat
regular seasonal epidemics of influenza and rare pandemics. The aim of this study was to …