Complement system part I–molecular mechanisms of activation and regulation
NS Merle, SE Church, V Fremeaux-Bacchi… - Frontiers in …, 2015 - frontiersin.org
Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …
against pathogens and in host homeostasis. The complement system is initiated by …
The role of the anaphylatoxins in health and disease
A Klos, AJ Tenner, KO Johswich, RR Ager, ES Reis… - Molecular …, 2009 - Elsevier
The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …
Mechanism of activation and biased signaling in complement receptor C5aR1
The complement system plays an important role in the innate immune response to invading
pathogens. The complement fragment C5a is one of its important effector components and …
pathogens. The complement fragment C5a is one of its important effector components and …
International union of basic and clinical pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors
A Klos, E Wende, KJ Wareham, PN Monk - Pharmacological reviews, 2013 - ASPET
The activation of the complement cascade, a cornerstone of the innate immune response,
produces a number of small (74–77 amino acid) fragments, originally termed …
produces a number of small (74–77 amino acid) fragments, originally termed …
The role of complement in biomaterial-induced inflammation
Biomaterials are regularly used in various types of artificial tissues and organs, such as
oxygenators, plasmapheresis equipment, hemodialysers, catheters, prostheses, stents …
oxygenators, plasmapheresis equipment, hemodialysers, catheters, prostheses, stents …
Function, structure and therapeutic potential of complement C5a receptors
PN Monk, AM Scola, P Madala… - British journal of …, 2007 - Wiley Online Library
Complement fragment (C) 5a is a 74 residue pro‐inflammatory polypeptide produced during
activation of the complement cascade of serum proteins in response to foreign surfaces such …
activation of the complement cascade of serum proteins in response to foreign surfaces such …
Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs),
Membrane proteins, encoded by∼ 20% of genes in almost all organisms, including humans,
are critical for cellular communication, electrical and ion balances, structural integrity of the …
are critical for cellular communication, electrical and ion balances, structural integrity of the …
Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors
JA Ballesteros, L Shi, JA Javitch - Molecular Pharmacology, 2001 - ASPET
The availability of a high-resolution structure of rhodopsin now allows us to reconsider
research attempts to understand structure-function relationships in other G protein-coupled …
research attempts to understand structure-function relationships in other G protein-coupled …
Orthosteric and allosteric action of the C5a receptor antagonists
The C5a receptor (C5aR) is a G-protein-coupled receptor (GPCR) that can induce strong
inflammatory response to the anaphylatoxin C5a. Targeting C5aR has emerged as a novel …
inflammatory response to the anaphylatoxin C5a. Targeting C5aR has emerged as a novel …
A chemogenomic analysis of the transmembrane binding cavity of human G‐protein‐coupled receptors
JS Surgand, J Rodrigo, E Kellenberger… - Proteins: Structure …, 2006 - Wiley Online Library
The amino acid sequences of 369 human nonolfactory G-protein-coupled receptors
(GPCRs) have been aligned at the seven transmembrane domain (TM) and used to extract …
(GPCRs) have been aligned at the seven transmembrane domain (TM) and used to extract …