[HTML][HTML] Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …
The vital role for nitric oxide in intraocular pressure homeostasis
Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …
[HTML][HTML] Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-
wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide …
wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide …
Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression
JE Craig, X Han, A Qassim, M Hassall… - Nature …, 2020 - nature.com
Glaucoma, a disease characterized by progressive optic nerve degeneration, can be
prevented through timely diagnosis and treatment. We characterize optic nerve photographs …
prevented through timely diagnosis and treatment. We characterize optic nerve photographs …
[HTML][HTML] Cell atlas of the human fovea and peripheral retina
Most irreversible blindness results from retinal disease. To advance our understanding of
the etiology of blinding diseases, we used single-cell RNA-sequencing (scRNA-seq) to …
the etiology of blinding diseases, we used single-cell RNA-sequencing (scRNA-seq) to …
RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation
L Jiang, J Wang, K Wang, H Wang… - Blood, The Journal …, 2021 - ashpublications.org
Abstract Ferroportin (FPN), the body's sole iron exporter, is essential for maintaining
systemic iron homeostasis. In response to either increased iron or inflammation, hepatocyte …
systemic iron homeostasis. In response to either increased iron or inflammation, hepatocyte …
Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis
Increased intraocular pressure (IOP) represents a major risk factor for glaucoma, a prevalent
eye disease characterized by death of retinal ganglion cells; lowering IOP is the only proven …
eye disease characterized by death of retinal ganglion cells; lowering IOP is the only proven …
The genetic basis for adult onset glaucoma: recent advances and future directions
Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
Update on the genetics of primary open-angle glaucoma
Affecting nearly 80 million individuals, glaucoma is the number one cause of irreversible
blindness in the world. This ocular disease describes a set of optic neuropathies of which …
blindness in the world. This ocular disease describes a set of optic neuropathies of which …
[HTML][HTML] Molecular genetics of glaucoma: Subtype and ethnicity considerations
Glaucoma, the world's leading cause of irreversible blindness, is a complex disease, with
differential presentation as well as ethnic and geographic disparities. The multifactorial …
differential presentation as well as ethnic and geographic disparities. The multifactorial …