The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

By providing spatial, molecular and morphological data over time, live-cell imaging can
provide a deeper understanding of the cellular and signalling events that determine cancer …

The low photostability of fluorescent proteins is a limiting factor in many applications of
fluorescence microscopy. Here we present StayGold, a green fluorescent protein (GFP) …

Bioluminescence is a natural light source based on luciferase catalysis of its substrate
luciferin. We performed directed evolution on firefly luciferase using a red-shifted and highly …

Skeletal muscle regenerates through the activation of resident stem cells. Termed satellite
cells, these normally quiescent cells are induced to proliferate by wound-derived signals …

The past decade has witnessed an explosion in the use of super-resolution fluorescence
microscopy methods in biology and other fields. Single-molecule localization microscopy …

Fluorescence microscopy is an invaluable tool in the biosciences, a genuine workhorse
technique offering exceptional contrast in conjunction with high specificity of labelling with …

The global demand for data storage is currently outpacing the world's storage capabilities.
DNA, the carrier of natural genetic information, offers a stable, resource-and energy-efficient …

Uncovering the mechanisms of virus infection and assembly is crucial for preventing the
spread of viruses and treating viral disease. The technique of single-virus tracking (SVT) …

The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of
debate, in large part because of the lack of insight into underlying mechanisms. Here we …