Somatosensory and autonomic neuronal regulation of the immune response

S Udit, K Blake, IM Chiu - Nature Reviews Neuroscience, 2022 - nature.com
Bidirectional communication between the peripheral nervous system (PNS) and the immune
system is a crucial part of an effective but balanced mammalian response to invading …

A review of vagus nerve stimulation as a therapeutic intervention

RL Johnson, CG Wilson - Journal of inflammation research, 2018 - Taylor & Francis
In this review, we provide an overview of the US Food and Drug Administration (FDA)-
approved clinical uses of vagus nerve stimulation (VNS) as well as information about the …

Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury

M Hanscom, DJ Loane… - The Journal of Clinical …, 2021 - Am Soc Clin Investig
Traumatic brain injury (TBI) is a chronic and progressive disease, and management requires
an understanding of both the primary neurological injury and the secondary sequelae that …

Neuronal regulation of immunity: why, how and where?

M Schiller, TL Ben-Shaanan, A Rolls - Nature Reviews Immunology, 2021 - nature.com
Neuroimmunology is one of the fastest-growing fields in the life sciences, and for good
reason; it fills the gap between two principal systems of the organism, the nervous system …

A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut

Y Zhu, KA Meerschaert, S Galvan-Pena, NR Bin… - Science, 2024 - science.org
Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense.
However, the matrix of interactions between arrays of molecularly defined neuron subsets …

Hypertension-linked pathophysiological alterations in the gut

MM Santisteban, Y Qi, J Zubcevic, S Kim… - Circulation …, 2017 - Am Heart Assoc
Rationale: Sympathetic nervous system control of inflammation plays a central role in
hypertension. The gut receives significant sympathetic innervation, is densely populated …

Current directions in the auricular vagus nerve stimulation I–a physiological perspective

E Kaniusas, S Kampusch, M Tittgemeyer… - Frontiers in …, 2019 - frontiersin.org
Electrical stimulation of the auricular vagus nerve (aVNS) is an emerging technology in the
field of bioelectronic medicine with applications in therapy. Modulation of the afferent vagus …

Neuroimmune interactions in peripheral organs

RGJ Klein Wolterink, GS Wu, IM Chiu… - Annual review of …, 2022 - annualreviews.org
Interactions between the nervous and immune systems were recognized long ago, but
recent studies show that this crosstalk occurs more frequently than was previously …

Manipulation of the inflammatory reflex as a therapeutic strategy

MJ Kelly, C Breathnach, KJ Tracey, SC Donnelly - Cell Reports Medicine, 2022 - cell.com
The cholinergic anti-inflammatory pathway is the efferent arm of the inflammatory reflex, a
neural circuit through which the CNS can modulate peripheral immune responses. Signals …

Anti‐inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation

B Bonaz, V Sinniger, S Pellissier - The Journal of physiology, 2016 - Wiley Online Library
Brain and viscera interplay within the autonomic nervous system where the vagus nerve
(VN), containing approximately 80% afferent and 20% efferent fibres, plays multiple key …