Heat shock proteins and cancer

J Wu, T Liu, Z Rios, Q Mei, X Lin, S Cao - Trends in pharmacological …, 2017 - cell.com
Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding
and maturation whose expression is induced by heat shock or other stressors. The major …

HSP70 and HSP90 in cancer: cytosolic, endoplasmic reticulum and mitochondrial chaperones of tumorigenesis

Z Albakova, Y Mangasarova, A Albakov… - Frontiers in …, 2022 - frontiersin.org
HSP70 and HSP90 are two powerful chaperone machineries involved in survival and
proliferation of tumor cells. Residing in various cellular compartments, HSP70 and HSP90 …

Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential

T Liu, CK Daniels, S Cao - Pharmacology & therapeutics, 2012 - Elsevier
Heat shock cognate protein 70 (HSC70) is a constitutively expressed molecular chaperone
which belongs to the heat shock protein 70 (HSP70) family. HSC70 shares some of the …

The role of proteomics in defining the human embryonic secretome

MG Katz-Jaffe, S McReynolds… - Molecular human …, 2009 - academic.oup.com
Non-invasive gamete and embryo assessment is considered an important focus in assisted
reproductive technologies (ART). Currently, the selection of embryos for transfer is based on …

IGF-binding protein 2–oncogene or tumor suppressor?

A Pickard, DJ McCance - Frontiers in endocrinology, 2015 - frontiersin.org
The role of insulin-like growth factor binding protein 2 (IGFBP2) in cancer is unclear. In
general, IGFBP2 is considered to be oncogenic and its expression is often observed to be …

Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids

HR Kumar, X Zhong, DJ Hoelz, FJ Rescorla… - Pediatric surgery …, 2008 - Springer
Introduction Solid tumors, such as neuroblastoma (NB), are associated with a
heterogeneous cell environment. Multicellular tumor spheroid (MCTS) cultures have been …

Overexpression of Hsc70 promotes proliferation, migration, and invasion of human glioma cells

G Sun, Y Cao, Y Xu, D Huai, P Chen… - Journal of cellular …, 2019 - Wiley Online Library
Migration and invasion are often recognized as the main reasons for the high recurrence
and death rates of glioma and limit the efficacy of surgery and other antitumor therapies. In …

[HTML][HTML] Embryology in the era of proteomics

MG Katz-Jaffe, S McReynolds - Fertility and sterility, 2013 - Elsevier
Proteomic technologies have begun providing evidence that viable embryos possess
unique protein profiles. Some of these potential protein biomarkers have been identified as …

Intact protein analysis of ubiquitin in cerebrospinal fluid by multiple reaction monitoring reveals differences in Alzheimer's disease and frontotemporal lobar …

P Oeckl, P Steinacker, CAF von Arnim… - Journal of proteome …, 2014 - ACS Publications
The impairment of the ubiquitin-proteasome system (UPS) is thought to be an early event in
neurodegeneration, and monitoring UPS alterations might serve as a disease biomarker …

The SODyssey: superoxide dismutases from biochemistry, through proteomics, to oxidative stress, aging and nutraceuticals

A D'Alessandro, L Zolla - Expert review of proteomics, 2011 - Taylor & Francis
A total of 40 years have already passed since the pioneering work of McCord and Fridovich
on erythrocuprein superoxide dismutase (SOD) activity. This modern scientific 'Odyssey'has …