[HTML][HTML] Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory 'multi-omics' study to …

E Clarke, L Varela, RE Jenkins… - … and Biophysics Reports, 2024 - Elsevier
Osteoarthritis causes progressive joint deterioration, severe morbidity, and reduced mobility
in both humans and horses. Currently, osteoarthritis is diagnosed at late stages through …

[HTML][HTML] Therapeutic Application of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Domestic Animals

A Lanci, E Iacono, B Merlo - Animals, 2024 - mdpi.com
Simple Summary Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs)
have recently been described in human and veterinary medicine and great interest is …

Multi-omic temporal landscape of plasma and synovial fluid-derived extracellular vesicles using an experimental model of equine osteoarthritis

JR Anderson, E Johnson, R Jenkins… - International journal of …, 2023 - mdpi.com
Extracellular vesicles (EVs) contribute to osteoarthritis pathogenesis through their release
into joint tissues and synovial fluid. Synovial fluid-derived EVs have the potential to be direct …

Allogenic platelet-rich plasma and platelet-rich plasma extracellular vesicles alter the proteome of tenocytes in an in vitro equine model of tendon inflammation: A pilot …

E Clarke, A Jensen, A Gillen, D Bardell, M Senior… - bioRxiv, 2024 - biorxiv.org
Background: Tendon injuries are common in horses, often resulting in a high risk of reinjury.
Hemoderivative therapeutics including platelet-rich plasma (PRP) show promise but …

Extracellular vesicles in osteoarthritis: from biomarkers to therapeutic potential

EJ Clarke, MJ Peffers - UK-Vet Equine, 2023 - magonlinelibrary.com
Equine osteoarthritis is a leading welfare concern. Currently, it can only be diagnosed in its
late stages–radiographically and upon clinical examination. There are no curative …

Exploring the Role of Extracellular Vesicles in Equine Musculoskeletal Pathologies and Associated Regenerative Therapies

EJ Clarke - 2023 - search.proquest.com
Horses are used in a variety of disciplines, including dressage, show jumping, eventing and
racing. Thus, the equine athlete is predisposed to the development of musculoskeletal …

[HTML][HTML] Plasma and synovial fluid extracellular vesicles display altered microRNA profiles in horses with naturally occurring post-traumatic osteoarthritis: an …

SS Connard, AM Gaesser, EJ Clarke… - Journal of the …, 2024 - Am Vet Med Assoc
Representative images from radiocarpal, middle carpal, and metacarpophalangeal joints
classified as advanced post-traumatic osteoarthritis (PTOA) based on the modified …