Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …

Recent clinical trials have demonstrated the ability to durably control cancer in some
patients by manipulating T lymphocytes. These immunotherapies are revolutionizing cancer …

Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast
cells form a heterogeneous population of immune cells with differences in their ultra …

Mast cells are tissue-resident, innate immune cells that play a key role in the inflammatory
response and tissue homeostasis. Mast cells accumulate in the tumor stroma of different …

Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives
many of the cancer" hallmarks" through downstream activation of the gp130/STAT3 …

Epidemiological studies propose a protective role for dietary fiber in colon cancer (CRC).
One possible mechanism of fiber is its fermentation property in the gut and ability to change …

The human intestine retains a complex microbial ecosystem, which performs crucial
functions that impact on host health. Several studies have indicated that intestinal dysbiosis …

The identification of intestinal stem cells as well as their malignant counterparts, colon
cancer stem cells, has undergone rapid development in recent years. Under physiological …

Mast cells can function as effector and immunoregulatory cells in immunoglobulin E–
associated allergic disorders, as well as in certain innate and adaptive immune responses …

Abstract Interleukin (IL)-10 is elevated in cancer and is thought to contribute to immune
tolerance and tumor growth. Defying these expectations, the adoptive transfer of IL-10 …