Given its safety and apparent low aqueous solubility, borneol may serve as a matrix forming
component of anti-solvent based in situ forming matrixes (ISMs) for crevicular pocket …

Modulation with the suppression of infection and inflammation is essential to the successful
treatment of periodontitis. An aqueous insoluble hydrophobic anti-inflammatory compound …

Solvent exchange-induced in situ forming gel (ISG) is currently an appealing dosage form
for periodontitis treatment via localized injection into the periodontal pocket. This study aims …

Periodontitis is a widespread oral health problem caused by bacterial infections that lead to
tooth loss and other systemic diseases. The aim of this study was to provide an alternative …

Abstract N-methyl pyrrolidone (NMP), dimethyl sulfoxide (DMSO), 2-pyrrolidone (PYR) and
eutectic (1: 1 menthol: camphor) were used as solvents for bleached shellac in doxycycline …

Localized intra-periodontal pocket drug delivery using an injectable in situ forming gel is an
effective periodontitis treatment. The aqueous insoluble property of rosin is suitable for …

Cholesterol has been widely used in drug delivery systems including implant. Doxycycline
hyclate (DH)-loaded cholesterol in situ forming gels using N-methyl pyrrolidone as a solvent …

Zein is composed of nonpolar amino acids and is a water-insoluble protein used as the
matrix-forming agent of localized in situ forming gel (ISG). Therefore, this study prepared …

Eudragit RS (ERS), a quaternary polyacrylate positively charged polymer, exhibits a very
low permeability and swells in aqueous media independently of pH without dissolving …

Solvent exchange-induced in situ forming gel (ISG) has emerged as a versatile drug delivery
system, particularly for periodontal pocket applications. In this study, we developed …