Principles and dynamics of spindle assembly checkpoint signalling
AD McAinsh, GJPL Kops - Nature Reviews Molecular Cell Biology, 2023 - nature.com
The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …
The four causes: the functional architecture of centromeres and kinetochores
AD McAinsh, AL Marston - Annual review of genetics, 2022 - annualreviews.org
Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
Distinct roles of RZZ and Bub1-KNL1 in mitotic checkpoint signaling and kinetochore expansion
Summary The Mad1-Mad2 heterodimer is the catalytic hub of the spindle assembly
checkpoint (SAC), which controls M phase progression through a multi-subunit anaphase …
checkpoint (SAC), which controls M phase progression through a multi-subunit anaphase …
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona
V Cmentowski, G Ciossani, E d'Amico… - The EMBO …, 2023 - embopress.org
Chromosome biorientation on the mitotic spindle is prerequisite to errorless genome
inheritance. CENP‐E (kinesin‐7) and dynein–dynactin (DD), microtubule motors with …
inheritance. CENP‐E (kinesin‐7) and dynein–dynactin (DD), microtubule motors with …
Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin
Cytoplasmic Dynein 1, or Dynein, is a microtubule minus end–directed motor. Dynein
motility requires Dynactin and a family of activating adaptors that stabilize the Dynein …
motility requires Dynactin and a family of activating adaptors that stabilize the Dynein …
[HTML][HTML] Non-centrosomal microtubules at kinetochores promote rapid chromosome biorientation during mitosis in human cells
Proper segregation of chromosomes during mitosis depends on" amphitelic attachments"—
load-bearing connections of sister kinetochores to the opposite spindle poles via bundles of …
load-bearing connections of sister kinetochores to the opposite spindle poles via bundles of …
[HTML][HTML] Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression
Error-free chromosome segregation in mitosis and meiosis relies on the assembly of a
microtubule-based spindle that interacts with kinetochores to guide chromosomes to the cell …
microtubule-based spindle that interacts with kinetochores to guide chromosomes to the cell …
Evolutionary dynamics of the spindle assembly checkpoint in eukaryotes
The tremendous diversity in eukaryotic life forms can ultimately be traced back to
evolutionary modifications at the level of molecular networks. Deep understanding of these …
evolutionary modifications at the level of molecular networks. Deep understanding of these …
Orchestration of the spindle assembly checkpoint by CDK1‐cyclin B1
In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐
kinetochore attachments during capture of chromosomes by the mitotic spindle. Spindle …
kinetochore attachments during capture of chromosomes by the mitotic spindle. Spindle …
Dynein at the kinetochore
R Gassmann - Journal of cell science, 2023 - journals.biologists.com
The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …