Therapeutic potential of ectopic olfactory and taste receptors
SJ Lee, I Depoortere, H Hatt - Nature Reviews Drug Discovery, 2019 - nature.com
Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and
gustatory taste bud cells, where they transmit real-time sensory signals to the brain …
gustatory taste bud cells, where they transmit real-time sensory signals to the brain …
Structural diversity of G protein-coupled receptors and significance for drug discovery
MC Lagerström, HB Schiöth - Nature reviews Drug discovery, 2008 - nature.com
G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors
and also the targets of many drugs. Understanding of the functional significance of the wide …
and also the targets of many drugs. Understanding of the functional significance of the wide …
Cellular source and mechanisms of high transcriptome complexity in the mammalian testis
Understanding the extent of genomic transcription and its functional relevance is a central
goal in genomics research. However, detailed genome-wide investigations of transcriptome …
goal in genomics research. However, detailed genome-wide investigations of transcriptome …
Visualizing an olfactory sensory map
P Mombaerts, F Wang, C Dulac, SK Chao, A Nemes… - Cell, 1996 - cell.com
We have developed a genetic approach to visualize axons from olfactory sensory neurons
expressing a given odorant receptor, as they project to the olfactory bulb. Neurons …
expressing a given odorant receptor, as they project to the olfactory bulb. Neurons …
[HTML][HTML] Human olfactory receptors: novel cellular functions outside of the nose
D Maßberg, H Hatt - Physiological reviews, 2018 - journals.physiology.org
Olfactory receptors (ORs) are not exclusively expressed in the olfactory sensory neurons;
they are also observed outside of the olfactory system in all other human tissues tested to …
they are also observed outside of the olfactory system in all other human tissues tested to …
[HTML][HTML] A spatial map of olfactory receptor expression in the Drosophila antenna
Insects provide an attractive system for the study of olfactory sensory perception. We have
identified a novel family of seven transmembrane domain proteins, encoded by 100 to 200 …
identified a novel family of seven transmembrane domain proteins, encoded by 100 to 200 …
G protein–coupled receptor kinases
JA Pitcher, NJ Freedman… - Annual review of …, 1998 - annualreviews.org
G protein–coupled receptor kinases (GRKs) constitute a family of six mammalian
serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein …
serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein …
Topographic organization of sensory projections to the olfactory bulb
The detection of odorant receptor mRNAs within the axon terminals of sensory neurons has
permitted us to ask whether neurons expressing a given receptor reject their axons to …
permitted us to ask whether neurons expressing a given receptor reject their axons to …
Calcium channels in the development, maturation, and function of spermatozoa
A Darszon, T Nishigaki, C Beltran… - Physiological …, 2011 - journals.physiology.org
A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …
A novel family of genes encoding putative pheromone receptors in mammals
C Dulac, R Axel - Cell, 1995 - cell.com
In mammals, olfactory sensory perception is mediated by two anatomically and functionally
distinct sensory organs: the main olfactory epithelium (MOE) and the vomeronasal organ …
distinct sensory organs: the main olfactory epithelium (MOE) and the vomeronasal organ …