Therapeutic potential of ectopic olfactory and taste receptors

SJ Lee, I Depoortere, H Hatt - Nature Reviews Drug Discovery, 2019 - nature.com
Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and
gustatory taste bud cells, where they transmit real-time sensory signals to the brain …

Structural diversity of G protein-coupled receptors and significance for drug discovery

MC Lagerström, HB Schiöth - Nature reviews Drug discovery, 2008 - nature.com
G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors
and also the targets of many drugs. Understanding of the functional significance of the wide …

Cellular source and mechanisms of high transcriptome complexity in the mammalian testis

M Soumillon, A Necsulea, M Weier, D Brawand… - Cell reports, 2013 - cell.com
Understanding the extent of genomic transcription and its functional relevance is a central
goal in genomics research. However, detailed genome-wide investigations of transcriptome …

Visualizing an olfactory sensory map

P Mombaerts, F Wang, C Dulac, SK Chao, A Nemes… - Cell, 1996 - cell.com
We have developed a genetic approach to visualize axons from olfactory sensory neurons
expressing a given odorant receptor, as they project to the olfactory bulb. Neurons …

[HTML][HTML] Human olfactory receptors: novel cellular functions outside of the nose

D Maßberg, H Hatt - Physiological reviews, 2018 - journals.physiology.org
Olfactory receptors (ORs) are not exclusively expressed in the olfactory sensory neurons;
they are also observed outside of the olfactory system in all other human tissues tested to …

[HTML][HTML] A spatial map of olfactory receptor expression in the Drosophila antenna

LB Vosshall, H Amrein, PS Morozov, A Rzhetsky… - Cell, 1999 - cell.com
Insects provide an attractive system for the study of olfactory sensory perception. We have
identified a novel family of seven transmembrane domain proteins, encoded by 100 to 200 …

G protein–coupled receptor kinases

JA Pitcher, NJ Freedman… - Annual review of …, 1998 - annualreviews.org
G protein–coupled receptor kinases (GRKs) constitute a family of six mammalian
serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein …

Topographic organization of sensory projections to the olfactory bulb

R Vassar, SK Chao, R Sitcheran, JM Nun, LB Vosshall… - Cell, 1994 - cell.com
The detection of odorant receptor mRNAs within the axon terminals of sensory neurons has
permitted us to ask whether neurons expressing a given receptor reject their axons to …

Calcium channels in the development, maturation, and function of spermatozoa

A Darszon, T Nishigaki, C Beltran… - Physiological …, 2011 - journals.physiology.org
A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

A novel family of genes encoding putative pheromone receptors in mammals

C Dulac, R Axel - Cell, 1995 - cell.com
In mammals, olfactory sensory perception is mediated by two anatomically and functionally
distinct sensory organs: the main olfactory epithelium (MOE) and the vomeronasal organ …