Mutations are the driving force of evolution, yet they underlie many diseases, in particular,
cancer. They are thought to arise from a combination of stochastic errors in DNA processing …

Cancer is underlined by genetic changes. In an unprecedented international effort, the Pan-
Cancer Analysis of Whole Genomes (PCAWG) of the International Cancer Genome …

Neuroblastoma is a pediatric solid tumor characterized by strong clinical heterogeneity.
Although clinical risk-defining genomic alterations exist in neuroblastomas, the mutational …

The cancer cell fraction (CCF), or proportion of cancerous cells in a tumor containing a
single-nucleotide variant (SNV), is a fundamental statistic used to quantify tumor …

Systematic DNA sequencing of cancer samples has highlighted the importance of two
aspects of cancer genomics: intra-tumor heterogeneity (ITH) and mutational processes …

Cancer results from an evolutionary process that yields a heterogeneous tumor with distinct
subpopulations and varying sets of somatic mutations. This perspective discusses …

Intra-tumor heterogeneity is a phenomenon in which mutation profiles differ from cell to cell
within the same tumor and is observed in almost all tumors. Understanding intra-tumor …

Chromosomal instability is a characteristic hallmark of cancer. It is providing part of the
genomic variation that makes cancer so heterogeneous and difficult to treat. Consequently …

Time series data play a crucial role in many applications, such as biology, medicine,
economics, engineering and others. One of the most powerful approaches for time series is …

The possibility to sequence DNA in cancer samples has triggered much effort recently to
identify the forces at the genomic level that shape tumorigenesis and cancer progression. It …