Huntington disease (HD) is a debilitating, currently incurable disease. Protein aggregation
and metabolic deficits are pathological hallmarks but their link to neurodegeneration and …

Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly,
plays a complex role in multiple physiological and pathophysiological processes by …

Abstract Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a
progressive autosomal dominant neurodegenerative disease caused by abnormal CAG …

Mitochondrial dysfunction and cognitive impairment are widespread phenomena among the
elderly, being crucial factors that contribute to neurodegenerative diseases. Nuclear factor …

Neurodegeneration refers to the selective and progressive loss-of-function and atrophy of
neurons, and is present in disorders such as Alzheimer's, Huntington's, and Parkinson's …

Mitochondrial deregulation has gained increasing support as a pathological mechanism in
Huntington's disease (HD), a genetic-based neurodegenerative disorder caused by CAG …

A major advance in the study of Huntington's disease (HD) has been the development of
human disease models employing induced pluripotent stem cells (iPSCs) derived from …

Neurodegenerative diseases are characterized by adverse cellular environments and
pathological alterations causing neurodegeneration in distinct brain regions. This …

Huntington disease (HD) is caused by an expanded polyglutamine mutation in huntingtin
(mHTT) that promotes prominent atrophy in the striatum and subsequent psychiatric …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease. It is
caused by the expansion of the CAG trinucleotide repeat sequence in the HTT gene. HD …