Home to a culturally heterogeneous population, India is also a melting pot of genetic
diversity. The population architecture characterized by multiple endogamous groups with …

Copy number variants (CNVs), deletions and duplications of segments of DNA, account for
at least five times more variable base pairs in humans than single-nucleotide variants …

Copy number variations occur frequently in the genome and are a significant source of
human genetic variation accounting for disease. Recently, we discovered a common …

While single nucleotide polymorphism (SNP) is typically the variant of choice for population
genetics, copy number variation (CNV) which comprises insertion, deletion and duplication …

During the course of the COVID-19 pandemic, large-scale genome sequencing of SARS-
CoV-2 has been useful in tracking its spread and in identifying variants of concern (VOC) …

APOBEC3B, in addition to other members of the APOBEC3 gene family, has recently been
intensively studied due to its identification as a gene whose activation in cancer is …

Background Genetic differences in the target proteins, metabolizing enzymes and
transporters that contribute to inter-individual differences in drug response are not integrated …

Admixture mapping has been useful in identifying genetic variations linked to phenotypes,
adaptation and diseases. Copy number variations (CNVs) represents genomic structural …

Human APOBEC3 cytidine deaminases are intrinsic resistance factors to HIV-1. However,
HIV-1 encodes a viral infectivity factor (Vif) that degrades APOBEC3 proteins. In vitro …

There have been concerted efforts toward cataloging rare and deleterious variants in
different world populations using high‐throughput genotyping and sequencing‐based …