An essential component of the chromatin remodeling machinery is NURF (Nucleosome
Remodeling Factor), the founding member of the ISWI family of chromatin remodeling …

Conspectus Inhibitor discovery for protein–protein interactions has proven difficult due to the
large protein surface areas and dynamic interfaces involved. This is particularly the case …

Accurate reconstruction of the regulatory networks that control gene expression is one of the
key current challenges in molecular biology. Although gene expression and chromatin state …

Histone lysine acetylation is a key component of epigenetic regulation of gene transcription.
Bromodomains, found in histone acetyl transferases and other chromatin-associated …

Bromodomain PHD finger transcription factor (BPTF) is the largest subunit of nucleosome
remodeling factor (NURF), a member of the ISWI chromatin-remodeling complex. However …

Background Chromatin regulatory factors are emerging as important genes in cancer
development and are regarded as interesting candidates for novel targets for cancer …

YEATS domain (YD) containing proteins are an emerging class of epigenetic targets in drug
discovery. Dysregulation of these modified lysine‐binding proteins has been linked to the …

Background: Bromodomain PHD finger transcription factor (BPTF) plays an important role in
chromatin remodeling, but its functional role in tumor progression is incompletely …

We describe a 19F NMR method for detecting bromodomain–ligand interactions using
fluorine-labeled aromatic amino acids due to the conservation of aromatic residues in the …

Bromodomain-containing protein dysregulation is linked to cancer, diabetes, and
inflammation. Selective inhibition of bromodomain function is a newly proposed therapeutic …