The cytosine analogues 5‐azacytosine (azacytidine) and 2′‐deoxy‐5‐azacytidine
(decitabine) are the currently most advanced drugs for epigenetic cancer therapies. These …

The DNA methyltransferase (DNMT) inhibitors azacytidine and decitabine are the most
successful epigenetic drugs to date and are still the most widely used as epigenetic …

The extent and biological impact of RNA cytosine methylation are poorly understood, in part
owing to limitations of current techniques for determining the targets of RNA …

The initiation and progression of cancer is controlled by both genetic and epigenetic events.
Unlike genetic alterations, which are almost impossible to reverse, epigenetic aberrations …

Green fluorescent proteins (GFPs) and variants thereof are widely used to study protein
localization and dynamics. We engineered a specific binder for fluorescent proteins based …

DNMT1 is recruited by PCNA and UHRF1 to maintain DNA methylation after replication.
UHRF1 recognizes hemimethylated DNA substrates via the SRA domain, but also …

Genome-wide DNA methylation patterns are frequently deregulated in cancer. There is
considerable interest in targeting the methylation machinery in tumor cells using nucleoside …

Role of DNA damage and demethylation on anticancer activity of DNA methyltransferase
inhibitors (DNMTi) remains undefined. We report the effects of DNMT1 gene …

Aim Recent evidence suggests that several dietary polyphenols may exert their
chemopreventive effect through epigenetic modifications. Curcumin is one of the most …

Virtual screening is increasingly being used in drug discovery programs with a growing
number of successful applications. Experimental methodologies developed to speed up the …