For a long time, scientists have tried to describe disorders just by genetic or environmental
factors. However, the role of epigenetics in human diseases has been considered from a …

Eosinophils derive from the bone marrow and circulate at low levels in the blood in healthy
individuals. These granulated cells preferentially leave the circulation and marginate to …

The increase of allergic diseases in the industrialized world has often been explained by a
decline in infections during childhood. The immunological explanation has been put into the …

Allergic rhinitis, asthma, and atopic eczema are among the commonest causes of chronic ill
health. These diseases are increasing in prevalence, and they add considerably to the …

The molecular mechanisms underlying the initiation of innate and adaptive proallergic Th2-
type responses in the airways are not well understood. IL-33 is a new member of the IL-1 …

There is increasing evidence that inflammatory mechanisms other than eosinophilic
inflammation may be involved in producing the final common pathway of enhanced …

Dendritic cells (DCs) are generally held responsible for initiating and maintaining allergic T
helper 2 (TH2)-cell responses to inhaled allergens in asthma. Although the epithelium was …

The effects of maternal smoking during pregnancy and childhood environmental tobacco
smoke (ETS) exposure on asthma and wheezing were investigated in 5,762 school-aged …

Tolerance is the usual outcome of inhalation of harmless antigen, yet T helper (Th) type 2
cell sensitization to inhaled allergens induced by dendritic cells (DCs) is common in atopic …

Discusses the development of the immune system during pregnancy and early life. Cell
populations and their role in the allergic response; Development of immune competence; …