Skeletal muscle and the nervous system depend on efficient protein quality control, and they
express chaperones and cochaperones at high levels to maintain protein homeostasis …

The metazoan Hsp70 disaggregase protects neurons from proteotoxicity that arises from the
accumulation of misfolded protein aggregates. Hsp70 and its co-chaperones disassemble …

The hematopoietic system plays a critical role in establishing the proper response against
invading pathogens or in removing cancerous cells. Furthermore, deregulations of the …

A tight regulation of transcription factor activity is critical for proper development. For
instance, modifications of RUNX transcription factors dosage are associated with several …

As molecular chaperones, DnaJs play critical roles in maintaining cytoplasmic structure and
resisting various stresses. However, the functions of DnaJs in insects are poorly understood …

Myeloid leukemia factors (MLF1 and MLF2) are proteins associated with leukemia and
several other cancers. However, little is known about the regulatory mechanisms underlying …

Macrophages are well known for their phagocytic functions in innate immunity across
species. In mammals, they rapidly consume a large amount of energy by shifting their …

Background The eukaryotic membrane vesicles contain specific sets of proteins that
determine vesicle function and shuttle with specific destination. Giardia lamblia contains …

The SWI/SNF (or BAF) complex is an essential chromatin remodeler that regulates DNA
accessibility at developmental genes and enhancers. SWI/SNF subunits are among the most …

Myeloid leukemia factor (MLF) plays an important role in development, cell cycle, myeloid
differentiation, and regulates the RUNX transcription factors. However, the function of MLF in …