Chemical modifications are necessary to ensure the metabolic stability and efficacy of
oligonucleotide-based therapeutics. Here, we describe analyses of the α-(l)-threofuranosyl …

Nucleic acids serve a dual role as both genetic materials in living organisms and versatile
molecular tools for various applications. Threose nuclei acid (TNA) stands out as a synthetic …

Xeno-nucleic acid (XNA) aptamers based on evolvable non-natural genetic polymers hold
enormous potential as future diagnostic and therapeutic agents. However, time-consuming …

This feature article delves into the realm of α-L-threose nucleic acid (TNA), an artificial
nucleic acid analog characterized by a backbone comprising an unconventional four-carbon …

The human genome's nucleotide sequence variation, such as single nucleotide mutations,
can cause numerous genetic diseases. However, detecting nucleic acids accurately and …

Triple‐negative breast cancer (TNBC) remains a significant challenge in terms of treatment,
with limited efficacy of chemotherapy due to side effects and acquired drug resistance. In this …

Spinal muscular atrophy (SMA) is a severe neuromuscular disorder that is caused by
mutations in the survival motor neuron 1 (SMN1) gene, hindering the production of …

When the double-stranded helix of nucleic acids is influenced by conditions such as
increase the temperature of the solution, change pH and chemical agent (formamide …