Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

T cells orchestrate adaptive immunity against pathogens and other immune challenges, but
their dysfunction can also mediate the pathogenesis of cancer and autoimmunity. Metabolic …

The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT).
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …

LAG3 is an inhibitory receptor that is highly expressed on exhausted T cells. Although LAG3-
targeting immunotherapeutics are currently in clinical trials, how LAG3 inhibits T cell function …

The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …

The immune system employs recognition tools to communicate with its microbial
evolutionary partner. Among all the methods of microbial perception, T cells enable the …

CRISPR-based technologies represent a major breakthrough in biomedical science as they
offer a powerful platform for unbiased screening and functional genomics in various fields …

Nutrients are emerging regulators of adaptive immunity. Selective nutrients interplay with
immunological signals to activate mechanistic target of rapamycin complex 1 (mTORC1), a …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening
conditions triggered by multiple intra-and extra-pulmonary injury factors, characterized by …

The scandal of detecting the flavoring solvent propane-1, 2-diol (PD) in milk has brought a
crisis to the trust of consumers in the dairy industry, while its deposition and transformation …