Compelling evidence for the inherited nature of essential hypertension has led to extensive
research in rats and humans. Rats have served as the primary model for research on the …

The heritability of obesity has long been appreciated and the genetics of obesity has been
the focus of intensive study for decades. Early studies elucidating genetic factors involved in …

Background Common bean is the most important staple grain legume for direct human
consumption and nutrition. It complements major sources of carbohydrates, including …

Quinoa is a pseudocereal originating from the Andean regions. Despite quinoa's long
cultivation history, genetic analysis of this crop is still in its infancy. We aimed to localize …

Stable quantitative trait loci (QTL) are important for deployment in marker assisted selection
in wheat (Triticum aestivum L.) and other crops. We reported QTL discovery in wheat using a …

Within quantitative genetics, the term “epistasis” is used to broadly describe situations in
which combinations of genetic variants show nonadditive phenotypic effects (Phillips 1998 …

In this study, Tyler et al. analyzed the complex genetic architecture of metabolic disease-
related traits using the Diversity Outbred mouse population Genetic studies of …

The impact of a single genetic locus on multiple phenotypes, or pleiotropy, is an important
area of research. Biological systems are dynamic complex networks, and these networks …

Central metabolism is a coordinated network that is regulated at multiple levels by resource
availability and by environmental and developmental cues. Its genetic architecture has been …

With the large volume of clinical and epidemiological data being collected, increasingly
linked to extensive genotypic data, coupled with expanding high-performance computational …