[HTML][HTML] Viral proteases as therapeutic targets

T Majerová, J Konvalinka - Molecular aspects of medicine, 2022 - Elsevier
Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and
herpesviruses―code for a protease, which is indispensable for viral maturation and …

Bats, civets and the emergence of SARS

LF Wang, BT Eaton - Wildlife and emerging zoonotic diseases: the biology …, 2007 - Springer
Severe acute respiratory syndrome (SARS) was the first pandemic transmissible disease of
previously unknown aetiology in the twenty-first century. Early epidemiologic investigations …

[HTML][HTML] Zoonotic origins of human coronavirus 2019 (HCoV-19/SARS-CoV-2): why is this work important?

G Wong, YH Bi, QH Wang, XW Chen, ZG Zhang… - Zoological …, 2020 - ncbi.nlm.nih.gov
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by infection with
human coronavirus 2019 (HCoV-19/SARS-CoV-2/2019-nCoV), is a global threat to the …

Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of …

S Liu, G Xiao, Y Chen, Y He, J Niu, CR Escalante… - The Lancet, 2004 - thelancet.com
Background Studies on the fusion-inhibitory peptides derived from the heptad repeat 1 and
2 (HR1 and HR2) regions of the HIV-1 envelope glycoprotein gp41 provided crucial …

Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein

Q Huang, L Yu, AM Petros, A Gunasekera, Z Liu… - Biochemistry, 2004 - ACS Publications
The severe acute respiratory syndrome (SARS) virus belongs to the Coronaviridea family of
viruses. Its virion encodes several proteins including a replicase and four structural proteins …

Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly …

Y He, H Lu, P Siddiqui, Y Zhou… - The Journal of Immunology, 2005 - journals.aai.org
The spike (S) protein of severe acute respiratory syndrome associated coronavirus (SARS-
CoV) is a major antigenic determinant capable of inducing protective immunity. Recently, a …

[HTML][HTML] SARS-associated coronavirus transmitted from human to pig

W Chen, M Yan, L Yang, B Ding, B He… - Emerging infectious …, 2005 - ncbi.nlm.nih.gov
Conclusions We have shown that human SARS-CoV can infect domesticated mammals, in
particular, the pig. The direct source of SARS-CoV transmission to the identified infected …

Analysis of synonymous codon usage in SARS Coronavirus and other viruses in the Nidovirales

W Gu, T Zhou, J Ma, X Sun, Z Lu - Virus research, 2004 - Elsevier
In this study, we calculated the codon usage bias in severe acute respiratory syndrome
Coronavirus (SARSCoV) and performed a comparative analysis of synonymous codon …

[HTML][HTML] Antibody responses to individual proteins of SARS coronavirus and their neutralization activities

M Qiu, Y Shi, Z Guo, Z Chen, R He, R Chen, D Zhou… - Microbes and …, 2005 - Elsevier
A novel coronavirus, the severe acute respiratory syndrome (SARS) coronavirus (SARS-
CoV), was identified as the causative agent of SARS. The profile of specific antibodies to …

Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: implication for developing SARS diagnostics …

Y He, Y Zhou, H Wu, B Luo, J Chen, W Li… - The Journal of …, 2004 - journals.aai.org
The spike (S) protein of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV)
is not only responsible for receptor binding and virus fusion, but also a major Ag among the …