Osteochondral (OC) repair is an extremely challenging topic due to the complex biphasic
structure and poor intrinsic regenerative capability of natural osteochondral tissue. In …

The socioeconomic impact of osteochondral (OC) damage has been increasing steadily
over time in the global population, and the promise of tissue engineering in generating …

One promising strategy to reconstruct osteochondral defects relies on 3D bioprinted three-
zonal structures comprised of hyaline cartilage, calcified cartilage, and subchondral bone …

Regenerative engineering holds the potential to treat clinically pervasive osteochondral
defects (OCDs). In a synthetic materials-guided approach, the scaffold's chemical and …

Rheumatoid arthritis (RA) is a self-immune inflammatory disease characterized by joint
damage. A series of cytokines are involved in the development of RA. Oncostatin M (OSM) is …

The homeostasis of osteochondral tissue is tightly controlled by articular cartilage
chondrocytes and underlying subchondral bone osteoblasts via different internal and …

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Objective Focal adhesion kinase (FAK) has critical functions in proliferation and
differentiation of many cell types, however, the role of FAK on BMP9-induced osteogenic …

Due to the high incidence of cartilage-related pathologies such as focal defects and
osteoarthritis, strategies are needed to restore the structure and function of osteochondral …

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease comparing the
inflammation of synovium. Macrophage-like synoviocytes and fibroblast-like synoviocytes …