Revealing quinquennial anticancer journey of morpholine: A SAR based review
Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a
moiety of great significance. It forms an important intermediate in many industrial and …
moiety of great significance. It forms an important intermediate in many industrial and …
Recent developments in the functionalization of betulinic acid and its natural analogues: a route to new bioactive compounds
JLC Sousa, CSR Freire, AJD Silvestre, AMS Silva - Molecules, 2019 - mdpi.com
Betulinic acid (BA) and its natural analogues betulin (BN), betulonic (BoA), and 23-
hydroxybetulinic (HBA) acids are lupane-type pentacyclic triterpenoids. They are present in …
hydroxybetulinic (HBA) acids are lupane-type pentacyclic triterpenoids. They are present in …
Saponins and their derivatives: potential candidates to alleviate anthracycline-induced cardiotoxicity and multidrug resistance
PR Qu, ZL Jiang, PP Song, LC Liu, M Xiang… - Pharmacological …, 2022 - Elsevier
Anthracyclines (ANTs) continue to play an irreplaceable role in oncology treatment.
However, the clinical application of ANTs has been limited. In the first place, ANTs can …
However, the clinical application of ANTs has been limited. In the first place, ANTs can …
Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29)
A novel family of betulinic acid analogues, carrying a triazole unit at C-3 attached through a
linker, was synthesized by the application of azide-alkyne “Click reaction”. These were …
linker, was synthesized by the application of azide-alkyne “Click reaction”. These were …
A novel triazole derivative of betulinic acid induces extrinsic and intrinsic apoptosis in human leukemia HL-60 cells
In an attempt to arrive at more potent cytotoxic agent than the bioactive natural product
betulinic acid, influence of small structural modifications of its 1, 2, 3 triazole derivatives …
betulinic acid, influence of small structural modifications of its 1, 2, 3 triazole derivatives …
Synthesis of betulinic acid derivatives with modified a‐rings and their application as potential drug candidates
L Borkova, J Hodon, M Urban - Asian Journal of Organic …, 2018 - Wiley Online Library
Abstract This Focus Review summarizes recent advances in the synthesis of betulinic acid
derivatives with modified A‐rings. It also focuses on their application as potential therapeutic …
derivatives with modified A‐rings. It also focuses on their application as potential therapeutic …
Synthesis, biological evaluation of fluorescent 23-hydroxybetulinic acid probes, and their cellular localization studies
23-Hydroxybetulinic acid (23-HBA) is a complex lupane triterpenoid, which has attracted
increasing attention as an anticancer agent. However, its detailed mechanism of anticancer …
increasing attention as an anticancer agent. However, its detailed mechanism of anticancer …
Design and synthesis of NAD (P) H: Quinone oxidoreductase (NQO1)-activated prodrugs of 23-hydroxybetulinic acid with enhanced antitumor properties
H Zhu, L Lu, W Zhu, Y Tan, Y Duan, J Liu, W Ye… - European Journal of …, 2022 - Elsevier
A series of NQO1 selectively activated prodrugs were designed and synthesized by
introducing indolequinone moiety to the C-3, C-23 or C-28 position of 23-hydroxybetulinic …
introducing indolequinone moiety to the C-3, C-23 or C-28 position of 23-hydroxybetulinic …
Novel soloxolone amides as potent anti-glioblastoma candidates: design, synthesis, in silico analysis and biological activities in vitro and in vivo
AV Markov, AA Ilyina, OV Salomatina, AV Sen'kova… - Pharmaceuticals, 2022 - mdpi.com
The modification of natural or semisynthetic triterpenoids with amines can be explored as a
promising strategy for improving their pharmacological properties. Here, we report the …
promising strategy for improving their pharmacological properties. Here, we report the …
A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells
Background Elevated production of reactive oxygen species (ROS) and an altered redox
state have frequently been observed in hepatocellular carcinoma (HCC); therefore, selective …
state have frequently been observed in hepatocellular carcinoma (HCC); therefore, selective …