Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long
been considered an important component of learning and memory. Computational and …

Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Dendritic spines mediate most excitatory neurotransmission in the nervous system, so their
function must be critical for the brain. Spines are biochemical compartments but might also …

Synapses store information by long-lasting modifications of their structure and molecular
composition, but the precise chronology of these changes has not been studied at single …

The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

In vivo optogenetics and photopharmacology are two techniques for controlling neuronal
activity that have immense potential in neuroscience research. Their applications in tether …

Dendritic spines are small protrusive structures on dendritic surfaces, and function as
postsynaptic compartments for excitatory synapses. Plasticity of spine structure is associated …

Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the
postsynaptic part of most excitatory synapses and are major sites of information processing …

Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …

Structural genomic variations represent a major driving force of evolution, and a burst of
large segmental gene duplications occurred in the human lineage during its separation from …