Insight into the three-dimensional architecture of RNA is essential for understanding its
cellular functions. However, even the classic transfer RNA structure contains features that …

One of the most important resources for researchers of noncoding RNAs is the information
available in public databases spread over the internet. However, the effective exploration of …

Motivation The accuracy of RNA secondary and tertiary structure prediction can be
significantly improved by using structural restraints derived from evolutionary coupling or …

With the dramatic increase in RNA 3D structure determination in recent years, we now know
that RNA molecules are highly structured. Moreover, knowledge of RNA 3D structures has …

Advances in sequencing technology have made abundant RNA sequence information
available, but the challenge of how to interpret these data remains. The RNA sequence …

Motivation: Several dynamic programming algorithms for predicting RNA structures with
pseudoknots have been proposed that differ dramatically from one another in the classes of …

The 3-dimensional fold of an RNA molecule is largely determined by patterns of
intramolecular hydrogen bonds between bases. Predicting the base pairing network from …

T-box riboswitches are modular bacterial noncoding RNAs that sense and regulate amino
acid availability through direct interactions with tRNAs. Between the 5′ anticodon-binding …

Eukaryotic initiation factor eIF4E performs a key early step in translation by specifically
recognizing the m 7 GpppN cap structure at the 5′ end of cellular mRNAs. Many viral …

Prequeuosine (preQ1) riboswitches are RNA regulatory elements located in the 5′ UTR of
genes involved in the biosynthesis and transport of preQ1, a precursor of the modified base …