The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …

Understanding the topological configurations of chromatin may reveal valuable insights into
how the genome and epigenome act in concert to control cell fate during development …

Human cell reprogramming technologies offer access to live human neurons from patients
and provide a new alternative for modeling neurological disorders in vitro. Neural electrical …

The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster
within regions enriched for genes encoding developmentally important transcription factors …

Pluripotent stem cells (PSCs) are capable of dynamic interconversion between distinct
substates; however, the regulatory circuits specifying these states and enabling transitions …

The remarkable developmental potential and replicative capacity of human embryonic stem
(ES) cells promise an almost unlimited supply of specific cell types for transplantation …

Parkinson's disease is a widespread condition caused by the loss of midbrain neurons that
synthesize the neurotransmitter dopamine. Cells derived from the fetal midbrain can modify …

Demyelination contributes to loss of function after spinal cord injury, and thus a potential
therapeutic strategy involves replacing myelin-forming cells. Here, we show that …

The long-term goal of nuclear transfer or alternative reprogramming approaches is to create
patient-specific donor cells for transplantation therapy, avoiding immunorejection, a major …