In humans, various genetic defects or age-related diseases, such as diabetic retinopathies,
glaucoma, and macular degeneration, cause the death of retinal neurons and profound …

Müller glia originate from neuroepithelium and are the principal glial cells in the retina.
During retinal development, Müller glia are one of the last cell types to be born. In lower …

Multiplexed modulation of endogenous genes is crucial for sophisticated gene therapy and
cell engineering. CRISPR–Cas12a systems enable versatile multiple-genomic-loci targeting …

Direct reprogramming of retinal Müller glia is a promising avenue for replacing
photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions …

Despite the therapeutic promise of direct reprogramming, basic principles concerning fate
erasure and the mechanisms to resolve cell identity conflicts remain unclear. To tackle these …

The ability to regenerate tissues varies between species and between tissues within a
species. Mammals have a limited ability to regenerate tissues, whereas zebrafish possess …

Neuronal degeneration in the zebrafish retina stimulates Müller glia (MG) to proliferate and
generate multipotent progenitors for retinal repair. Controlling this proliferation is critical to …

Tgf-β signaling is a major antiproliferative pathway governing different biological functions,
including cellular reprogramming. Upon injury, Müller glial cells of zebrafish retina …

Epithelial–mesenchymal transitions (EMTs) are the epitome of cell plasticity in embryonic
development and cancer; during EMT, epithelial cells undergo dramatic phenotypic changes …

Neuroretinal diseases are the predominant cause of irreversible blindness worldwide,
mainly due to photoreceptor loss. Currently, there are no radical treatments to fully reverse …