CCN1/CYR61: the very model of a modern matricellular protein
LF Lau - Cellular and Molecular Life Sciences, 2011 - Springer
Abstract CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein
that plays essential roles in cardiovascular development during embryogenesis, and …
that plays essential roles in cardiovascular development during embryogenesis, and …
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
DJ Manalo, A Rowan, T Lavoie, L Natarajan, BD Kelly… - Blood, 2005 - ashpublications.org
Abstract Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding
angiogenic growth factors, which are secreted by hypoxic cells and stimulate endothelial …
angiogenic growth factors, which are secreted by hypoxic cells and stimulate endothelial …
Functions and mechanisms of action of CCN matricellular proteins
CC Chen, LF Lau - The international journal of biochemistry & cell biology, 2009 - Elsevier
Members of the CCN (CYR61/CTGF/NOV) family have emerged as dynamically expressed,
extracellular matrix-associated proteins that play critical roles in cardiovascular and skeletal …
extracellular matrix-associated proteins that play critical roles in cardiovascular and skeletal …
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas
Affymetrix and spotted oligonucleotide microarrays were used to assess global differential
gene expression comparing normal human melanocytes with six independent melanoma …
gene expression comparing normal human melanocytes with six independent melanoma …
The unfolded protein response: a novel component of the hypoxic stress response in tumors
DE Feldman, V Chauhan, AC Koong - Molecular Cancer Research, 2005 - AACR
Hypoxia is a physiologically important endoplasmic reticulum (ER) stress that is present in
all solid tumors. Numerous clinical studies have shown that tumor hypoxia predicts for …
all solid tumors. Numerous clinical studies have shown that tumor hypoxia predicts for …
Hypoxic gene expression and metastasis
Solid tumors possess malformed vasculature that results in the exposure of tumor cells to a
low oxygen environment. Tumor hypoxia has been demonstrated in human and mouse …
low oxygen environment. Tumor hypoxia has been demonstrated in human and mouse …
A pivotal role of cyclic AMP-responsive element binding protein in tumor progression
R Abramovitch, E Tavor, J Jacob-Hirsch, E Zeira… - Cancer research, 2004 - AACR
Tumor microenvironment controls the selection of malignant cells capable of surviving in
stressful and hypoxic conditions. The transcription factor, cyclic AMP-responsive element …
stressful and hypoxic conditions. The transcription factor, cyclic AMP-responsive element …
Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61
J Chen, X Zhou, J Yang, Q Sun, Y Liu, N Li… - Cell death & …, 2020 - nature.com
Circular RNAs (circRNAs) are emerging regulators in the development of human cancers.
However, the role of circRNAs in melanoma is poorly understood. Microarray analysis and …
However, the role of circRNAs in melanoma is poorly understood. Microarray analysis and …
Conjunction junction, what's the function? CCN proteins as targets in fibrosis and cancers
A Leask - American Journal of Physiology-Cell Physiology, 2020 - journals.physiology.org
Cellular communication network (CCN) proteins are matricellular proteins that coordinate
signaling among extracellular matrix, secreted proteins, and cell surface receptors. Their …
signaling among extracellular matrix, secreted proteins, and cell surface receptors. Their …