Aneuploidy, or imbalanced chromosome number, has profound effects on eukaryotic cells.
In humans, aneuploidy is associated with various pathologies, including cancer, which …

Microglia are critical in brain development and Alzheimer's disease (AD) etiology. Down
syndrome (DS) is the most common genetic developmental disorder and risk factor for AD …

Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting
downstream of the trisomy remain ill defined. Using complementary genomics analyses, we …

Mitochondria are prominently understood as power houses producing ATP the primary
energy currency of the cell. However, mitochondria are also known to play an important role …

Abstract Trisomy 21 (T21) causes Down syndrome (DS), but the mechanisms by which T21
produces the different disease spectrum observed in people with DS are unknown. We …

It is widely assumed that cells must be physically isolated to study their molecular profiles.
However, intact tissue samples naturally exhibit variation in cellular composition, which …

Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). The
understanding of genotype–phenotype relationships, the identification of driver genes and …

With an incidence of~ 1 in 800 births, Down syndrome (DS) is the most common
chromosomal condition linked to intellectual disability worldwide. While the genetic basis of …

SARS-CoV-2 infection has spread uncontrollably worldwide while it remains unknown how
vulnerable populations, such as Down syndrome (DS) individuals are affected by the COVID …

Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological
hallmarks of DS include atypical central nervous system development that manifests …