Ferroptosis is recognized as a new form of regulated cell death which is initiated by severe
lipid peroxidation relying on reactive oxygen species (ROS) generation and iron overload …

Background Iron is essential for many types of biological processes. However, excessive
iron can be cytotoxic and can lead to many diseases. Since ferroptosis, which is an iron …

As an important trace element, iron plays an essential role in many biology processes like
cell proliferation, metabolism, and mitochondrial function. However, the disruption of iron …

Despite advances in cancer research, cancer is still one of the leading causes of death
worldwide. An early diagnosis substantially increases the survival rate and treatment …

Ferroptosis is a new mode of cell death that is characterized by the excessive accumulation
of iron and lipid peroxides. It has unique morphological changes and disparate biochemical …

Iron is an essential trace element in the human body, and its deficiency or excess induces
diverse biological processes. Iron dysregulation is closely associated with the initiation and …

Ferroptosis is a newly discovered form of iron-dependent cell death, which is different from
other death forms. The main characteristics of ferroptosis are:(1) Amino acid metabolism.(2) …

Stroke is a common disease in clinical practice, which seriously endangers people's
physical and mental health. The neurovascular unit (NVU) plays a key role in the occurrence …

Simple Summary Iron is the more abundant metal ion in humans. It is essential for life as it
has a role in various cellular processes involved, for instance, in cell metabolism and DNA …

Abstract Changes in reactive oxygen species (ROS) levels affect many aspects of cell
behavior. During carcinogenesis, moderate ROS production modifies gene expression to …