Cells live in a chemical environment and are able to orient towards chemical cues.
Unicellular haploid fungal cells communicate by secreting pheromones to reproduce …

Accurate decoding of spatial chemical landscapes is critical for many cell functions.
Eukaryotic cells decode local chemical gradients to orient growth or movement in productive …

Fungi exhibit an enormous variety of morphologies, including yeast colonies, hyphal
mycelia, and elaborate fruiting bodies. This diversity arises through a combination of polar …

An essential ability of many cell types is to detect stimuli in the form of shallow chemical
gradients. Such cues may indicate the direction that new growth should occur, or the …

How small eukaryotic cells can interpret dynamic, noisy, and spatially complex chemical
gradients to orient growth or movement is poorly understood. We address this question …

Abstract Design patterns are generalized solutions to frequently recurring problems. They
were initially developed by architects and computer scientists to create a higher level of …

Many intracellular signaling pathways are composed of molecular switches, proteins that
transition between two states—on and off. Typically, signaling is initiated when an external …

Directed cell growth or migration are critical for the development and function of many
eukaryotic cells. These cells develop a dynamic “front”(also called “polarity site”) that can …

Yeast decode pheromone gradients to locate mating partners, providing a model for
chemotropism. How yeast polarize toward a single partner in crowded environments is …

Many cells adjust the direction of polarized growth or migration in response to external
directional cues. The yeast Saccharomyces cerevisiae orient their cell fronts (also called …