The recognition of microbial or danger-associated molecular patterns by complement
proteins initiates a cascade of events that culminates in the activation of surface complement …

Although the complement system is primarily perceived as a host defence system, a more
versatile, yet potentially more harmful side of this innate immune pathway as an …

Chronic diabetes is associated with metabolic and haemodynamic stresses which can
facilitate modifications to DNA, proteins and lipids, induce cellular dysfunction and damage …

Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …

Sepsis, a common and potentially fatal systemic illness, is triggered by microbial infection
and often leads to impaired function of the lungs, kidneys or other vital organs. Since the …

The complement component C3 is a fundamental plasma protein for host defense, produced
largely by the liver. However, recent work has demonstrated the critical importance of tissue …

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of
potentially life-threatening autoimmune diseases. The main histological feature in the …

Complement is one of the most ancient defense systems. It gets strongly activated
immediately after acute injuries like trauma, burn, or sepsis and helps to initiate …

Complement and Toll‐like receptors (TLR s) play key roles in the host immune response
and are swiftly activated by infection or other types of immunological stress. This review …

We have previously reported that a group of host cellular microRNAs (miRNAs; miR-34a-5p,
miR-122-5p, miR-145-5p, miR-146a-5p, miR-210-3p) are released into the blood during …