The liver is a large highly vascularized organ with a central function in metabolic
homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to …

The unusual regenerative properties of the liver are a logical adaptation by organisms, as
the liver is the main detoxifying organ of the body and is likely to be injured by ingested …

Liver resection is the first-line treatment for primary liver cancers, providing the potential for a
cure. However, concerns about post-hepatectomy liver failure (PHLF), a leading cause of …

The liver can precisely regulate its growth and mass. Surgical resection of hepatic lobes or
hepatocyte loss caused by viral or chemical injury triggers hepatocyte replication while …

The ability of hepatocytes to enter the cell cycle and regenerate the liver after tissue loss
provides an in vivo model to study the regulation of proliferation and organ regeneration …

Acetaminophen (N-acetyl-para-aminophenol; APAP) overdose is the most common cause of
acute liver failure in the Western world, with limited treatment opportunities. For years …

The liver is unique in its ability to regenerate in response to injury. A number of evolutionary
safeguards have allowed the liver to continue to perform its complex functions despite …

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is
activated by many cytokines and growth factors and plays a key role in cell survival …

Acetaminophen (APAP) overdose results in acute liver failure and has limited treatment
options. Previous studies show that stimulating liver regeneration is critical for survival after …

The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling
pathway, activated by more than 50 cytokines or growth factors, plays critical roles in a wide …