Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

Stroke, a neurological disease, is one of the leading causes of death worldwide, resulting in
long-term disability in most survivors. Annual stroke costs in the United States alone were …

Biomarkers are measurable substances that could be used as objective indicators for
disease diagnosis, responses to treatments, and outcomes predictions. In this review, we …

Postoperative cognitive dysfunction (POCD) is common and is associated with poor
outcome. Neural circuit involvement in POCD is unknown. Lateral habenula (LHb) that …

Ischemic stroke continues to be one of the leading causes of death and disability in the adult
population worldwide. The currently used pharmacological methods for the treatment of …

Ischemic stroke (IS) is the second leading cause of death and disability in the world.
Pyroptosis, a form of programmed cell death initiated by caspases, participates in the …

A significant amount of evidence from the past few years has shown that Sirtuin 1 (SIRT1), a
histone deacetylase dinucleotide of nicotinamide adenine dinucleotide (NAD+) is closely …

Constitutive vesicle trafficking is the default pathway used by all cells for movement of
intracellular cargoes between subcellular compartments and in and out of the cell …

Ischemic stroke affects over 77 million people annually around the globe. Due to the
blockage of a blood vessel caused by a stroke, brain tissue becomes ischemic. While …