Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
Biomolecular condensates are membraneless intracellular assemblies that often form via
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …
[HTML][HTML] Phase separation and neurodegenerative diseases: a disturbance in the force
A Zbinden, M Pérez-Berlanga, P De Rossi… - Developmental cell, 2020 - cell.com
Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …
[HTML][HTML] Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
Patients with Coronavirus disease 2019 exhibit low expression of interferon-stimulated
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains
A Bremer, M Farag, WM Borcherds, I Peran… - Nature …, 2022 - nature.com
Prion-like low-complexity domains (PLCDs) have distinctive sequence grammars that
determine their driving forces for phase separation. Here we uncover the physicochemical …
determine their driving forces for phase separation. Here we uncover the physicochemical …
Molecular interactions underlying liquid− liquid phase separation of the FUS low-complexity domain
The low-complexity domain of the RNA-binding protein FUS (FUS LC) mediates liquid−
liquid phase separation (LLPS), but the interactions between the repetitive SYGQ-rich …
liquid phase separation (LLPS), but the interactions between the repetitive SYGQ-rich …
[HTML][HTML] Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis
A Prasad, V Bharathi, V Sivalingam… - Frontiers in molecular …, 2019 - frontiersin.org
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs
Tightly packed complexes of nucleocapsid protein and genomic RNA form the core of
viruses and assemble within viral factories, dynamic compartments formed within the host …
viruses and assemble within viral factories, dynamic compartments formed within the host …
[HTML][HTML] A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation
Many organisms evolved strategies to survive desiccation. Plant seeds protect dehydrated
embryos from various stressors and can lay dormant for millennia. Hydration is the key …
embryos from various stressors and can lay dormant for millennia. Hydration is the key …
[HTML][HTML] The molecular language of membraneless organelles
Eukaryotic cells organize their intracellular components into organelles that can be
membrane-bound or membraneless. A large number of membraneless organelles, including …
membrane-bound or membraneless. A large number of membraneless organelles, including …
Tau protein liquid–liquid phase separation can initiate tau aggregation
S Wegmann, B Eftekharzadeh, K Tepper… - The EMBO …, 2018 - embopress.org
The transition between soluble intrinsically disordered tau protein and aggregated tau in
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …